Development of a skin benign tumor, cancer and melanoma from the view point of morphofunctional zones
Development of a benign and malignant skin tumor in a morphofunctional zone in many respects depends on the quantity of cambial cells, which excite an electric field at their division, due to which the inactive Src-kinase, participating in a formation of the cytoskeleton and a differentiation, is expressed in cells. Decrease in cells number to 8 leads to formation of a benign tumor, and up to 6 – to malignant as this quantity of cambial cells can't express enough inactive Src-kinase, necessary for a normal cytoskeleton formation. The skin melanoma can develop without decrease in cambial cells number due to sharp redistribution between shares of inactive and the active Src-kinase, thus the cytoskeleton formation and cell differentiation fall.
2. Burova, EB., Gonchar, IV. and Nikolsky, NN. Stat1 and stat3 activation by oxidative stress in A431 cells involves src-dependent EGF receptor tranactivation. Tsitologiya. 2003.45(5):466-477.
3. Devary, Y., Gottlieb, RA., Smeal T. and Karin, M. The mammalian ultraviolet response is triggered by activation of Src tyrosine kinases. Cell. 1992.71(7):1081-1091.
4.Yagubov A.S. Danilenko V. I. Bogush I.G. Astemirova L.T. Stereomicroscopy in determination of symmetry of development of non-tumor processes and a cancer. Articles collection, devoted to the 80 anniversary of G.G. Avtandilov. Diagnostic medical morphometry. M, 2002. P. 137-142.
5. Yavisheva T.M. Shcherbakov S.D. Epithelial-stromal morphofunctional zones: structure and functions. Moscow, 2013.
6. Yavisheva T.M. Shcherbakov S. D.Development of melanoma and cancer without decreasing of cambial cells number in morphofunctional zones. Advances in Bioscience and Biotechnology. 2014.5:493-500.
7.Yavisheva, TM. and Shcherbakov, SD . Participation of an inactive and active Src-kinase in formation of a cytoskeleton and melanogenesis in Hep2 cells. International Journal of Current Microbiology and Applied Sciences. 2016.5(12):583-593
8. Yavisheva T.M. Shcherbakov, S.D., Golubeva I.S. Sharafutdinov G. Z. Savluchinskaya L.A. To a question of the structural organization of the basal layer and morphofunctional features of mouse epidermis cambial cells. Byulleten Eksperimentalnoi Biologii I Meditsiny 2004. 5: P. 584-588.
9. Yavisheva T.M. Shcherbakov S. D., Savluchinskaya L.A. Features of morphofunctional zones work in the normal epithelium, breast fibroadenoma and breast cancer. Dokl. AN . 2005 . 404(1): 125-128.
10.Yavisheva TM, Shcherbakov SD, Golubeva IS, Sharafutdinov GZ Interaction of cambial dermal cells (fibroblasts) and epidermis in morphofunctional area of mouse skin Byulleten Eksperimentalnoi Biologii I Meditsiny 2007 144 (5):748-753.
11.Yavisheva, TM., Shcherbakov, SD, Golubeva, IS Some aspects of morphofunctional organization of germinal regions of the hippocampus and olfactory bulb in young and old mice International journal of innovative studies in medical sciences 2017 l.(1):1-8.
Copyright (c) 2018 International Journal For Research In Health Sciences And Nursing (ISSN: 2208-2670)
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
In consideration of the journal, Green Publication taking action in reviewing and editing our manuscript, the authors undersigned hereby transfer, assign, or otherwise convey all copyright ownership to the Editorial Office of the Green Publication in the event that such work is published in the journal. Such conveyance covers any product that may derive from the published journal, whether print or electronic. Green Publication shall have the right to register copyright to the Article in its name as claimant, whether separately
or as part of the journal issue or other medium in which the Article is included.
By signing this Agreement, the author(s), and in the case of a Work Made For Hire, the employer, jointly and severally represent and warrant that the Article is original with the author(s) and does not infringe any copyright or violate any other right of any third parties, and that the Article has not been published elsewhere, and is not being considered for publication elsewhere in any form, except as provided herein. Each author’s signature should appear below. The signing author(s) (and, in