CT Imaging of Gastrointestinal Stromal Tumour: Case Report and Literature Review

Authors

  • Stoyanka Dineva Department of Radiology, Medical Institute of Ministry of Interior–Sofia, Skobelev blv 79 Sofia1606, Bulgaria
  • Dobrina Mlachkova Department of Nuclear Medicine, Medical Institute of Ministry of Interior – Sofia, Skobelev blv 79 Sofia1606, Bulgaria
  • Deyan Todorov Department of Surgery, Medical Institute of Ministry of Interior – Sofia, Skobelev blv 79 Sofia1606, Bulgaria

DOI:

https://doi.org/10.53555/hsn.v3i4.260

Keywords:

Gastrointestinal stromal tumor, sarcoma, stomach

Abstract

A gastrointestinal stromal tumour (GIST) is a type of soft tissue sarcoma that develops in the
digestive tract. Gastrointestinal stromal tumors (GIST) are the most common mesenchymal
neoplasms of the gastrointestinal tract with a malignant potential. However, uncommonly they
can be associated with synchronous tumors of different histogenesis. Most GISTs begin in the
stomach or small bowel, but they can develop anywhere along the digestive tract. About 6 out
of 10 (60%) of these tumours start in the stomach. Very rarely, they develop outside the
gastrointestinal tract.

Downloads

Download data is not yet available.

References

Agaimy A, Wunsch PH, Sobin LH, Lasota J, Miettinen M. Occurrence of othermalignancies in patients with gastrointestinal stromal tumours.SeminDiagn Pathol2006;23:120-129.

Agaimy A. Gastrointestinal stromal tumors (GIST) from risk stratification systems to the new TNM proposal: more questions than answers? A review emphasizing the need for a standardized GIST reporting. Int J Clin Exp Pathol 2010; 3(5): 461-71

Andtbacka RH, Ng CS, Scaife CL, et al. Surgical resection of gastrointestinal stromal tumors after treatment with imatinib. Ann Surg Oncol 2007; 14(1): 14-24

Blanke CD, Rankin C, Demetri GD, et al. Phase III randomized, intergroup trial assessing imatinib mesylate at two dose levels in patients with unresectable or metastatic gastrointestinal stromal tumors expressing the kit receptor tyrosine kinase: S0033. J Clin Oncol 2008; 26: 626-632

Casali PG, Le Cesne A, Velasco AP, et al. Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group Intergroup Randomized Trial in Collaboration With the Australasian Gastro-Intestinal Trials Group, UNICANCER, French Sarcoma Group, Italian Sarcoma Group, and Spanish Group for Research on Sarcomas. J Clin Oncol 2015; 33(36): 4276-4283

Casali PH, Garrett CR, Blackstein ME, et al. Updated results from a phase III trial of sunitinib in GIST patients (pts) for whom imatinib (IM) therapy has failed due to resistance or intolerance [abstract 9513] Proc Am Soc Clin Oncol 2006; 247.

Cirillo F.Neuroendocrine tumours and their association with rare tumours: observation of 4 cases.Eur Rev Med Pharmacol Sci2010;14:577-588.

Debiec-Rychter M, Sciot R, Le Cesne A, et al. KIT mutations and dose selection for imatinib in patients with advanced gastrointestinal stromal tumours. Eur J Cancer 2006; 42: 1093-103

DeMatteo RP, Ballman KV, Antonescu CR, et al. Placebo-Controlled Randomized Trialof Adjuvant Imatinib Mesylate Following the Resection of Localized, Primary Gastrointestinal Stromal Tumor (GIST). Lancet 2009; 373(9669): 1097-1104

Demetri GD, Reichardt P, Kang YK, et al. 2013. Efficacy and safety of regorafenib for advanced gastrointestinal stromal tumours after failure of imatinib and sunitinib (GRID): an international, multicentre, randomised, placebocontrolled, phase 3 trial. Lancet 2013; 381(9863): 295-302

Demetri GD, van Oosterom AT, Garrett CR, et al. Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial. Lancet 2006; 368: 1329-38

ESMO/ European Sarcoma Network Working Group. Gastrointestinal stromal tumours: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2014; 25(sup 3): iii21-iii26

Ferreira SS, Werutsky G, Marcelo GarciaToneto MG, et al. Synchronous gastrointestinal stromal tumours (GIST) and other primary cancers: Case series of a single institution experience.Intern J Surg2010;8:314-317.

Joensuu H, Eriksson M, Hall SK. Adjuvant Imatinib for High-Risk GI Stromal Tumor: Analysis of a Randomized Trial. J Clin Oncol 2016; 34(3): 244-50

Joensuu H, Eriksson M, Sundby Hall K, et al. One vs three years of adjuvant imatinib for operable gastrointestinal stromal tumor: a randomized trial. JAMA 2012; 307(12): 1265-1272

Lin YL, Wei CK, Chiang JK, Chou AL, Chen CW, Tseng CE. Concomitant gastric carcinoid and gastrointestinal, stromal tumours: a case report.World JGastroenterol2008;14:6100-6103.

Liszka L, Zielińska-Pająk E, Paja J, Gołka D, Huszno J. Coexistence of gastrointestinal stromal tumours with other neoplasms.J Gastroenterol2007; 42:641-649.

Miettinen M, Lasota J, et al. Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis. Arch Pathol Lab Med 2006; 130(10): 1466-78

NCCN. Soft Tissue Sarcoma Version I.2015. Accessed August 25, 2015 http://www.nccn.org/professionals/physician_gls/pdf/sarcoma.pdf

Nemes C, Rogojan L, Surdea-Blaga T, Seicean A, Dumitrascu DL, Ciuce C. Gastrointestinal stromal tumour (GIST) associated with synchronous colon adenocarcinoma -a case report.J Gastrointest Liver Dis2012;21:101-103.

Pusiol T, Zorzi MG, Morichetti G, Piscioli I, Scialpi M. Synchronous nonfunctional duodenal carcinoid and high risk gastrointestinal stromal tumour (GIST) of the stomach.Europ Rev Med Pharmacol Sciences2011;15:583-585.

Rubin BP, FLetcher JA, Fletcher CD. Molecular Insights into the Histogenesis and Pathogenesis of Gastrointestinal Stromal Tumors. Int J Surg Pathol. 2008 8(1): 5

Shariq O, Odedra A, Alexopoulos A-S, Gould S, Soobrah R. Synchronous occurrence of gastrointestinal stromal tumour and ovarian neoplasm in a patient presenting with acute cholecystitis.J Gastrointest Cancer2012;43:113-116.

Tran T, Davila JA, El-Serag HB. The epidemiology of malignant gastrointestinal stromal tumors: an analysis of 1,458 cases from 1992 to 2000. Am J Gastroenterol. 2005 100(1): 162

Downloads

Published

2017-04-30

How to Cite

Dineva, S., Mlachkova, D., & Todorov, D. (2017). CT Imaging of Gastrointestinal Stromal Tumour: Case Report and Literature Review. International Journal For Research In Health Sciences And Nursing, 3(4), 01–05. https://doi.org/10.53555/hsn.v3i4.260