The Relation Between Nutritional Status and Healing Time for Patients Undergoing Hematopoietic Stem Cells Transplantation Sample
DOI:
https://doi.org/10.53555/hsn.v4i12.1225Keywords:
Engraftment, Hematopoietic Stem Cell Transplantation, Malnutrition, Nutritional Status, ObesityAbstract
Background: Hematopoietic stem cell transplantation is considered a lifesaving procedure for many hematologic and non-hematologic malignancies. Multiple factors affect transplantation outcome as nutritional status of the patient either over nourished or undernourished. Malnutrition prior to transplant has been reported as a negative prognostic factor following Hematopoietic stem cell transplantation. A recent meta-analysis confirmed that obese recipient has increased risk of acute graft versus host disease and may have increased mortality rates.
Aim: Determine the relation between nutritional status and healing time for patients undergoing hematopoietic stem cell transplantation. The study was conducted at Al Mouwasat University Hospital, Alexandria University and Nasser Institute Hospital, Cairo.
Subjects: The study was conducted on a purposive sample of 40 patients who necessitate hematopoietic stem cell transplantation.
Tools: Two tools were used. Tool I: Socio demographic and clinical data of patients submitted to hematopoietic stem cells transplantation, structured interview schedule and Tool II: Patient’s nutritional assessment record prior to hematopoietic stem cells transplantation.
Results: The three quarters of patients were either overweight or obese pre transplantation, the underweight patients had the longest engraftment time and longest hospitalization, and it was observed that the more the body mass index (BMI) and body fat percent, the less time for engraftment.
Conclusion and Recommendations: it is necessary to initiate nutritional assessment and follow up for those patients to prevent malnutrition and to protect the borderline patients to become negatively malnourished and consequently affecting healing time negatively. Moreover, despite the obesity is a risk factor for graft versus host disease and transplantation complications, it is not dangerous as malnutrition in occurrence of late engraftment.
Downloads
References
Mahla RS. Stem Cells Applications in Regenerative Medicine and Disease Therapeutics. Int J Cell Biol 2016; 2016:6940283
Prohaska S, Weissman R. Biology of Hematopoietic Stem and Progenitor Cells. In: Appelbaum FR, Forman SJ, Negrin RS, Blume KJ (eds). Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation. USA: Wiley; 2009. 36-63.
Prochazkova M, Chavez MG, Prochazka J, Felfy H, Mushegyan V, Klein OD. Embryonic Versus Adult Stem Cells. In: Vishwakarma A, Sharpe P, Ramalingam M. Stem Cell Biology and Tissue Engineering in Dental Sciences. San Francisco: Science Direct; 2015. 249–62.
Lad DP, Malhotra P, Varma S. Hematopoietic Stem Cell Applications: Past, Present and Future. J Postgrad Med Educ Res 2012; 46(2):69-74.
European Society for Blood and Marrow Transplantation (EBMT). A Guide to the completion of the EBMT. 2016. Available at: https://www.google.com/url sa=t&rct=j&q=&esrc=s&source=web&cd=1&cad=rja&uact=8&ved=0ahUKEwj9wuThrrfbAhUFr6QKHZD0Cm0QFggmMAA&url=http%3A%2F%2Fwww.ebmt.org%2Fsites%2Fdefault%2Ffiles%2F2018-03%2FMEDAB%2520Forms%2520Manual.pdf&usg=AOvVaw3I7DWg1KkdxYiWIE6cxvJy Retrieved on: Feb, 2018
Aerts E, Babic A, Devine H, Kerache F, Mank A, Schouten H. Haematopoietic Stem Cell Mobilization and Apheresis: A Practical Guide for Nurses and Other Allied Health Care Professionals. European Group for Blood and Marrow Transplantation- Nurses Group (EBMT NC); 2009 .
Mahmoud HK, EL-Haddad AM, Fahmy OA, El-Emary M, Nassar A, Abdel-Mooti M. Hematopoietic stem cell transplantation in Egypt. Bone Marrow Transplantat 2008; 42: 576-80
Statistical records of Bone Marrow Transplant Unit, Nasser Institute Hospital at Cairo affiliated to Ministry of Health.
Sureda A, Bader P, Cesaro S, Dreger P, Duarte RF, Dufour C. Indications for allo- and auto-SCT for haematological diseases, solid tumours and immune disorders: current practice in Europe, 2015. Bone Marrow Transplantat 2015; 50:1037-56.
Muscaritoli M, Grieco G, Capria S, Iori AP, Fanelli FR. Nutritional and metabolic support in patients undergoing bone marrow transplantation. The American Journal of Clinical Nutrition 2002; 75(2): 183- 190
Horsley P, Bauer J, Gallagher B. Poor nutritional status prior to peripheral blood stem cell transplantation is associated with increased length of hospital stay. Bone Marrow Transplantat 2005; 35: 1113–116.
Akbulut G. Medical nutritional therapy in hematopoietic stem cell transplantation (HSCT). Int J Hematol Oncol 2013; 23(1):55-65
Bassim CW, Fassil H, Dobbin M, Steinberg SM, Baird K, Cole K. Malnutrition in patients with chronic GVHD. Bone Marrow Transplantation 2014; 49: 1300–306
Weiss BM, Vogl DT, Berger NA, Stadtmauer EA, Lazarus HM. Trimming the fat: obesity and hematopoietic cell transplantation. Bone Marrow Transplantat 2013; 48:1152-60
Hadjibabaie M, Iravani M, Taghizadeh M, Ataie-Jafari A, Shamshiri AR, Mousavi SA. Evaluation of nutritional status in patients undergoing hematopoietic SCT. Bone Marrow Transplantat 2008; 42(7): 469-73.
Hoffman R, Benz EJ, Silberstein LE, Heslop HE, Weitz JI, Anastasi J. Hematology Basic Principles and Practice. 6th ed. Canada: Elsevier Saunders; 201317. Sauer A, Alish C, Strausbaugh K, West K, Quatrara B. Nurses needed: identifying malnutrition in hospitalized older adults. Elsevier 2016; 2: 21-5
Jefferies D, Johnson M, Ravens J. Nurturing and nourishing: the nurses’ role in nutritional care. J Clin Nurs 2011; 20(3-4):317-30.
Yarbro CH, Wujcik D, Gobel BH. Cancer Nursing: Principles and Practice. 7th ed. Canada: Jones and Bartlett; 2011
Lavdaniti M. A nursing perspective of nutrition in cancer patients undergoing chemotherapy. Prog Health Sci 2014; 4(2):131-34
Tomblyn M, Chiller T, Einsele H, Gress R, Sepkowitz K, Storek J. Guidelines for preventing infectious complications among hematopoietic cell transplantation recipients: a global perspective. Biol Blood Marrow Transplant 2009; 15:1143-238
Food Safety. Gov. Food Safety for Cancer Patients. 2018. Available at: https://www.foodsafety.gov/risk/cancer/index.html. Retrieved on: Feb, 2018.
Habschmidt MG, Bacon CA, Gregoire MB, Rasmussen HE. Medical nutrition therapy provided to adult hematopoietic stem cell transplantation patients. Nutr Clin Pract 2012; 27(5):655-60.
Macris PC, McMillen KK. Nutrition Support of the Hematopoietic Cell Transplant Recipient. In: Forman S, Negrin R, Antin J, Appelbaum F (eds). Thomas’ Hematopoietic Cell Transplantation. 5th ed. Singapore: John Wiley & Sons, Ltd; 2016
Ezzone S, Pokorny K. Blood and Marrow Stem Cell Transplantation: Principles, Practice
and Nursing Insights. 3rd ed. United States of America. Jones &Bartlett; 2007.
Lee SY, Gallagher D. Assessment methods in human body composition. Curr Opin Clin Nutr Metab Care 2008; 11(5):566-72.
Rondel A, Langius J, De van M, Kruizenga H. The new ESPEN diagnostic criteria for malnutrition predict overall survival in hospitalised patients. Clin Nutr 2018; 37(1):163- 68.
Maziarz RT, Slater SS. Blood and Marrow Transplant Handbook: Comprehensive Guide for Patient Care. 2nd ed. New York: Springer; 2015
Marian M, Roberts S. Clinical Nutrition for Oncology Patients. United States of America: Jones and Bartlett; 2010.
Kondrup J, Allison S, Elia M, Vellas B, Plauth M. ESPEN Guidelines for Nutrition Screening 2002. Clin Nutr 2003; 22(4):415-21.
Kumar NB. Nutritional Management of Cancer Treatment Effects. Verlag Berlin Heidelberg: Springer; 2012.
Schutz Y, Kyle UUG , Pichard C. Fat-free mass index and fat mass index percentiles in Caucasians aged 18–98 y. Int J Obes Relat Metab Disord 2002; 26(7):953-60.
Sardesai VM. Introduction to Clinical Nutrition. 2nd ed. New York: Marcel Dekker; 2003.
Lee SY, Gallagher D. Assessment methods in human body composition. Curr Opin Clin Nutr Metab Care 2008; 11(5):566-72.
Kyle UG, Bosaeus I, De Lorenzo AD, Deurenberg P, Elia M, Manuel Gómez J, et al. Bioelectrical impedance analysis-part II: utilization in clinical practice. Clin Nutr 2004; 23:1430-53.
Latifi R, Merrell RC. Nutritional Support in Cancer and Transplant Patients. Georgetown, Texas, U.S.A: Landes Bioscience; 2001.
Jain S, Gautam V, Naseem S. Acute-phase proteins: As diagnostic tool. J Pharm Bioallied Sci 2011; 3(1): 118–27.38. El-Deeb DK. Nutritional Assessment of Children with Cancer Attending the Pediatric
Oncology Unit, Alexandria Main University Hospital, Egypt. Doctorate Dissertation. Faculty of Medicine: Alexandria University; 2016.
Unal D, Orhan O, Eroglu C, Kaplan B. Prealbumin is a more sensitive marker than albumin to assess the nutritional status in patients undergoing radiotherapy for head and neck cancer. Contemp Oncol (Pozn) 2013; 17(3):276-80.
Blaser BW, Kim HT, Alyea EP, Ho VT, Cutler C, Armand P, et al. Hyperlipidemia and Statin Use after Allogeneic Hematopoietic Stem Cell Transplantation. Biol Blood Marrow Transplant 2012; 18(4):575-83.
Baliga KV, Sharma PK, Prakash MS, Mostafi M. Lipid Profile in Transplant Patients: A Clinical Study. MJAFI 2002; 58:32-5.
Rolfes SR, Pinna K, Whitney E. Understanding Normal and Clinical Nutrition. 8th ed. Canada: Yolanda Cossio; 2009.
Shim JS, Oh K, Kim HC. Dietary assessment methods in epidemiologic studies. Epidemiol Health 2014; 36:e2014009.
Institute of Medicine (US) Committee on Dietary Risk Assessment in the WIC Program. Dietary Risk Assessment in the WIC Program. Washington (DC): National Academies Press (US); 2002.
Geirsdottir OG, Thorsdottir I. Nutritional status of cancer patients in chemotherapy; dietary intake, nitrogen balance and screening. Food Nutr Res 2008; 52: 10.
Lukmanji Z, Hertzmark E, Mlingi N, Assey V, Ndossi G, Fawzi W. Muhimbili University of Health and Allied Sciences (MUHAS), Dar es Salaam – Tanzania and Tanzania Food and Nutrition Centre (TFNC), Dar es Salaam – Tanzania and Harvard School of Public Health (HSPH), Boston, USA: Tanzania Food Composition Tables. 1st ed. Tanzania F: DeskTop Productions Limited; 2008.
Volp AC, De Oliveira FC, Alves RD, Esteves EA, Bressan YJ. Energy expenditure: components and evaluation methods. Nutr Hosp J. 2011; 26(3):430-40.
Ferrie S, Ward M. Back to basics: estimating energy requirements for adult hospital patients. Nutrition & Dietitics 2007; 64: 192- 99.
Yarbro CH, Wujcik D, Gobel BH. Cancer Nursing: principles and practice. 7th ed. Canada: Jones and Bartlett; 2011.
Lavdaniti M. A nursing perspective of nutrition in cancer patients undergoing chemotherapy. Prog Health Sci 2014; 4(2):131-34.
Maziarz RT, Slater SS. Blood and Marrow Transplant Handbook: Comprehensive Guide for Patient Care. 2nd ed. New York: Springer; 2015.
Beurer BF 100 Instructions for Use Manual: About the Device; Explanation of Symbols; Safety Notes. The Ultimate Manuals Library; 2018. Available at:
https://www.manualslib.com/manual/1082809/Beurer-Bf-100.html?page=14#manual
Dougherty L, Lister S. The Royal Marsden Manual of Clinical Nursing Procedures. 9th ed. Oxford: John Wiley & Sons, Ltd; 2015.
Webster-Gandy J, Madden A, Holdsworth M. Oxford Handbook of Nutrition and Dietetics. 2nd ed. United States: Oxford University Press; 2012.
Catharine Ross A, Caballero B, Cousins RJ, Tucker KL, Ziegler TR. Modern Nutrition in Health and Disease. 11th ed. China: Lippincott Williams & Wilkins; 2014.
High Institute of Public Health, Alexandria University. Food Composition Tables for Egypt; 2006.
Kirkpatrick LA, Feeney BC. A simple guide to IBM- SPSS statistics for version 20.0. Studented. Bemont, Calif: Wadsworth, Cengage Learning; 2013.58. Moriya N, Fegshan Yang, Steven T. Noise- related multi-variate optimal joint- analysis in longitudinal stochastic processes. Nova Sci Publishers 2008; 38(3):223-60.
Fabbro E, Baracos V, Wahnefried W, Bowling T, Hopkinson J, Bruera E. Nutrition and Cancer Patient. United States: Oxford University Press; 2010.
Barritta de Defranchi RL, Bordalejo A, Cañueto I, Villar A, Navarro E. Evolution of nutritional status in patients with autologous and allogeneic hematopoietic stem cell transplant. Support Care Cancer 2015; 23(5):1341-7.
Ferreira EE, Guerra DC, Baluz K, de Resende Furtado W, da Silva Bouzas LF. Nutritional status of patients submitted to transplantation of allogeneic hematopoietic stem cells: a retrospective study. Rev Bras Hematol Hemoter 2014; 36(6):414-9.
Schutz Y, Kyle UUG , Pichard C. Fat-free mass index and fat mass index percentiles in Caucasians aged 18–98 y. Int J Obes Relat Metab Disord 2002; 26(7):953-60.
Hadjibabaie M, Tabeefar H, Alimoghaddam K, Iravani M, Eslami K, Honarmand H. The relationship between body mass index and outcomes in leukemic patients undergoing allogeneic hematopoietic stem cell transplantation. Clin Transplant J 2012; 26: 149–155.
Rzepecki P, Barzal J, Sarosiek T, Szczylik C. Biochemical indices for the assessment of nutritional status during hematopoietic stem cell transplantation: are they worth using? A single center experience. Bone Marrow Transplantat 2007; 40:567-72.
Philibert D, Desmeules S, Filion A, Poirier M, Agharazii M. Incidence and severity of early electrolyte abnormalities following autologous haematopoietic stem cell transplantation. Nephrol Dial Transplant 2008; 23:359-63.
So EJ, Lee JS, Kim JY. Nutritional intake and nutritional status by the type of hematopoietic stem cell transplantation. Clin Nutr Res 2012; 1(1):3-12.
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
In consideration of the journal, Green Publication taking action in reviewing and editing our manuscript, the authors undersigned hereby transfer, assign, or otherwise convey all copyright ownership to the Editorial Office of the Green Publication in the event that such work is published in the journal. Such conveyance covers any product that may derive from the published journal, whether print or electronic. Green Publication shall have the right to register copyright to the Article in its name as claimant, whether separately
or as part of the journal issue or other medium in which the Article is included.
By signing this Agreement, the author(s), and in the case of a Work Made For Hire, the employer, jointly and severally represent and warrant that the Article is original with the author(s) and does not infringe any copyright or violate any other right of any third parties, and that the Article has not been published elsewhere, and is not being considered for publication elsewhere in any form, except as provided herein. Each author’s signature should appear below. The signing author(s) (and, in
