Characteristics of Breast Cancer in Men: A Single Case Analysis and Literature Review
Breast Cancer in Men: A Single Case
Keywords:breast cancer, male, BRCA2, histological grade
Breast cancer in men is a rare condition. It accounts for 1% of all diagnosed breast cancers worldwide and 1.5% of cancers affecting the male gender. Its clinical and morphological features as well as management are more or less similar to those found in women.We report the case of a 55-year-old man who presented with a nodule in the UIQ of the right breast following a chest trauma a few months earlier. Histological examination revealed invasive ductal carcinoma, Grade II (2 + 2 + 2) as per Elston and Ellis, Stage II (pT2Nx) on excisional biopsy. A mastectomy with lymph node excision was carried out. There was no residual tumor and all the lymph nodes were non-metastatic. Male breast cancer is also often associated with a mutation in the BRCA2 gene. Mammography and histology are the key diagnostic examinations. Recurrence and risk of developing other cancers are increased, especially in cases of genetic mutation. Monitoring of patients with such condition is therefore necessary.
- Martynowicz H, Medraś M, Andrzejak R. Occupational risk factors and male breast cancer. Med Pr. 2005; 56: 405-410.
- Arnould N, Pouget O, Gharbi M, et al. Breast cancer in men: are there similarities with breast cancer in women? Gynecol Obstet Fertil. 2006; 34: 413-419.
- Anderson WF, Althuis MD, Brinton LA, et al. Is male breast cancer similar or different than female breast cancer? Breast Cancer Res Treat. 2004; 83: 77-86.
- Brinton LA, Key TJ, Kolonel LN, et al. Prediagnostic sex steroid hormones in relation to male breast cancer risk. J Clin Oncol. 2015 Jun;33(18):2041–50.
- PDQ Adult Treatment Editorial Board . Male Breast Cancer Treatment (PDQ). Health professional Version. 2016. Feb 12.
- Weiss JR, Moysich KB, Swede H. Epidemiology of male breast cancer. Cancer Epidemiol. Biomarkers Prev. 2005;14(1):20–26.
- Giordano SH, Cohen DS, Buzdar AU, et al. Breast carcinoma in men: a population-based study. Cancer. 2004; 101: 51-57.
- Hogervorst F, Cornelis R, Bout M, et al. Rapid detection of BRCA1 mutations by the protein truncation test. Nat Genet. 1995; 10: 208-212.
- Yoneda S, Yoshikawa M, Yamane Y et al. Breast cancer developed in a male patient with liver cirrhosis bearing hepatocellular carcinoma. Suis J Gastroenterol. 2000; 95: 556-557.
- Meguerditchian AN, Falardeau M, Martin G. Male breast carcinoma. Can J Surg. 2002; 45: 296-302.
- Evans GF, Anthony T, Turnage RH, Schumpert TD, Levy KR, Amirkhan RH, Campbell TJ, Lopez J, Appelbaum AH. The diagnostic accuracy of mammography in the evaluation of male breast disease. Suis J Surg. 2001; 181 : 96-100.
- Joshi A, Kapila K, Verma K. Fine needle aspiration cytology in the management of male breast masses. Nineteen years of experience. Acta cytologica. 1999; 43: 334-338.
- Khan HN, Blamey RW. Endocrine treatment of physiological gynaecomastia. BMJ. 2003;327(7410):301–302.
- Giordano SH, Cohen DS, Buzdar AU, Perkins G, Hortobagyi GN. Breast carcinoma in men: a population-based study. Cancer 2004. 2004; 101 : 51-57.
- Giordano SH. A review of the diagnosis and management of male breast cancer Oncologist. 2005; 10 : 471–479.
- Hansen J. Elevated risk for male breast cancer after occupational exposure to gasoline and vehicular combustion products. Suis J Ind Med. 2000; 37 : 349–352.
- Giordano SH, Cohen DS, Buzdar AU, Perkins G, Hortobagyi GN. Breast carcinoma in men: a population-based study. Cancer. 2004;101(1):51–57.
- Donegan WL, Redlich PN, Lang PJ, Gall MT. Carcinoma of the breast in males: a multiinstitutional survey. Cancer. 1998;83(3):498–509.
- Renehan AG, Tyson M, Egger M, et al. Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet. 2008 Feb;371(9612):569–578.
- Speirs V, Shaaban AM, et al. The rising incidence of male breast cancer. Breast Cancer Res Treat. 2008 May;115(2):429–30.
- Tunon de Lara C, Goudy G, MacGrogan G, Durand M, Dilhuydy JM, Avril A, Stoeckle E, Bussières JE, Debled M, De Mascarel I, Mauriac L. Male breast cancer: a review of 52 cases collected at the Institute Bergonié (Bordeaux, France) from 1980 to 2004. Gynécologie Obstétrique & Fertilité 2008 Apr;36(4):386–394.
- Albo D, Ames FC, Hunt KK, Ross MI, Singletary SE, Kuerer HM. Evaluation of lymph node status in male breast cancer patients: a role for sentinel lymph node biopsy. Breast Cancer Res Treat. 2003;77(1):9–14.
- Yu E, Stitt L, Vujovic O, Joseph K, Assouline A, Younus J, et al. Male breast cancer prognostic factors versus female counterparts with propensity scores and matched-pair analysis. Cureus. 2015 Oct;7(10):e355.
How to Cite
Copyright (c) 2022 International Journal For Research In Biology & Pharmacy (ISSN: 2208-2093)
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
In consideration of the journal, Green Publication taking action in reviewing and editing our manuscript, the authors undersigned hereby transfer, assign, or otherwise convey all copyright ownership to the Editorial Office of the Green Publication in the event that such work is published in the journal. Such conveyance covers any product that may derive from the published journal, whether print or electronic. Green Publication shall have the right to register copyright to the Article in its name as claimant, whether separately
or as part of the journal issue or other medium in which the Article is included.
By signing this Agreement, the author(s), and in the case of a Work Made For Hire, the employer, jointly and severally represent and warrant that the Article is original with the author(s) and does not infringe any copyright or violate any other right of any third parties, and that the Article has not been published elsewhere, and is not being considered for publication elsewhere in any form, except as provided herein. Each author’s signature should appear below. The signing author(s) (and, in