A Clinical Evaluation of Anti-Inflammatory and Analgesic Activities of Curcuma longa Extract in Patients Suffering from Osteoarthritis of Knee(s) - An Open Labeled, Multi-Centric, Interventional, Prospective Study
Anti-Inflammatory and Analgesic Activities of Curcuma longa Extract in Osteoarthritis of Knee(s)
DOI:
https://doi.org/10.53555/ans.v8i2.2003Keywords:
OA disease, Osteoarthritis, Turmeric, Curcuma longaAbstract
Background: Curcumin, the principal curcuminoid in turmeric, is a biologically active phytochemical which may exert a chondroprotective effect through actions such as anti-inflammatory, anti-oxidative stress and anti-catabolic activity that are critical for mitigating OA disease pathogenesis and symptoms. A proprietary water soluble turmeric extract of Curcuma longa standardized to not less than 23% total Curcuminoids (AQUATURM®) was studied for its anti-inflammatory & analgesic activity.
Objective: The objective was to evaluate efficacy and safety of Curcuma longa Extract in patients suffering from osteoarthritis of knee(s).
Methodology: After the ethics committee’s approval, subsequent CTRI registration, 21 patients suffering from OA attending OPD of the study center and who consented, were enrolled in the study after all necessary investigations. Subjects were advised to take Curcuma longa extract 900 mg (prepared as powder packets) dissolved in water and consumed daily for a period of 90 days. After the baseline visit, subjects were called for follow-up visits on 30, 60, 90 days. All the subjects were closely monitored for any adverse events/ adverse drug reactions starting from the baseline visit.
Results:
The improvement in efficacy assessment parameters such as VAS Score of Knee(s) pain, WOMAC combined score, WOMAC Pain score, WOMAC Stiffness score and WOMAC Difficulty score was statistically significant (p < 0.05). At the end of study (90 days) the time taken to walk 50 feet was observed to be 20.18 ±3.02 sec which was found to be statistically significant. The study product was found to be safe and well tolerated.
Conclusion: It can be concluded that this proprietary Curcuma longa extract is a safe and effective natural supplement option for the management of osteoarthritis.
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