Glycemia and HBA1c with Patients Infected by SARS COV-2 in a Biochemical Laboratory in 2020

Authors

  • Ranaivosoa Miora Koloina Biologist, Laboratory of Biochemistry of Joseph Ravoahangy Andrianavalona University, Hospital Antananarivo, Madagascar
  • Rakotonjafiniarivo Faralahy Harisolofo Biologist, Laboratory of Biochemistry of Joseph Ravoahangy Andrianavalona University, Hospital Antananarivo, Madagascar
  • Raharilivasoa Fenohasina Medical Biology Student, Laboratory of Joseph Ravoahangy Andrianavalona University, Hospital Antananarivo, Madagascar
  • Rasamindrakotroka Andry Professor of Immunology, Laboratory of Training and Research in Medical Biology, University of Antananarivo, Madagascar

DOI:

https://doi.org/10.53555/bp.v7i11.1886

Keywords:

Antananarivo, Biochemistry, Glycemia, HbA1c, SRAS CoV-2

Abstract

Coronavirus disease 2019 is a viral zoonosis caused by the Severe Acute Respiratory Syndrome Coronavirus-2 strain of coronavirus. The aim of this study is to determine the glycaemic disturbances in patients infected with SARS CoV-2. This is a retrospective and descriptive study conducted at the Paraclinical Service of Training and Researches in Biochemistry at the University Hospital Center of Joseph Ravoahangy Andrianavalona, Antananarivo from January 1st to June 30th 2021. The data were collected from the laboratory analysis request forms. All test requests belonging to coronavirus-infected patients mentioned in the clinical information and involving a simultaneous fasting blood glucose and HbA1c test were included. Our study included 52 patients of whom 53.87% were male and 46.15% female. The average age was 58 years. The average blood glucose value was 10.78 mmol/l, that of HbA1c was 4.9%. The average blood glucose value was significantly higher with men than with women. The highest average blood glucose level (12.96 mmol/l) was found between the age group 35-45 years. The average HbA1c in the 35-45 age group was the highest but still within the normal range. Hyperglycaemia is frequently observed during SARS-CoV-2 infection in diabetics and non-diabetics by several mechanisms.

Downloads

Download data is not yet available.

References

World Health Organization; (2020). WHO Director-General’s remarks at the media briefing on 2019-nCoV on (11 February 2020). Available from: https://www.who.int/dg/speeches/detail/who-director-general-s-remarks-at-the-media-briefing-on-2019-ncov-on-11-february-2020.11.

MOUEDEN AM, BENLALDJ D, MESSAOUDI R, SEGHIER F. Profil hématologique des patients atteints de COVID-19 au niveau du CHU d’Oran en Algérie. ALGERIAN JOURNAL OF HEALTH SCIENCES 2021 ;3(2) :22-9.

Chaomin W, Xiaoyan C, Yanping C, Jia'an X, Xing Z et al.Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China. JAMA Intern Med 2020 ; 180(7):934-43.

Carrasco-Sánchez FJ, Carretero-Gómez J, Gómez-Huelgas R, Garcia-Ordoñez MA, Pardo-

Ortega MV et al. Stress-induced hyperglycemia on complications in non-critically elderly hospitalized patients. Rev Clin Esp 2018 ; 218:223–31. https://doi.org/10.1016/j.rce.2018.02.017.

Carrasco-Sánchez FJ, López-Carmona MD, Martínez-Marcos FJ, Pérez-Belmonte L M.,Hidalgo-Jiménez A et al. Admission hyperglycemia as a predictor of mortality in patients hospitalized with COVID-19 regardless of diabetes status: Data from the Spanish SEMI-COVID-19 Registry. Annals of Medicine 2020. DOI:10.1080/07853890.2020.1836566

American Diabetes Association, “Diabetes care in the hospital: standards of medical care in diabetes-2020,Diabetes Care 2020, 43(1) :193–202.

Omer A, Bengu S. Analyse rétrospéctive des patients atteints de pneumonie COVID-19 sévère traités par lopinavir/ritonavir : une comparaison avec des patients survivants et non survivants. Southern African Journal of Infectious Diseases 2020 ;35(1). A233.https://doi.org/10.4102/sajid.v35i1.233

Huang C, WangY, Li X, Ren L, Zhao J et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China, Lancet 2020 ;395(10223) :497-506.

Wang D, Hu B, Hu C, Zhu F, Liu X et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA 2020 ;323(11):1061-9.

ZhangJJ, Dong X, Cao YY, Yuan YD, Yang YB et al. Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China. Allergy 2020 ; 75(7):1730-41.

Derek M, Griffith, PhD, Garima S, MD et al. Men and COVID19: A biopsychosocial approach to understanding sex differences in mortality and recommandations for practice and policy interventios. Prev chronic dis2020 ; 17(E63)

Sama IE, Ravera A, Santema et al. Concentration plasmatique circulante de l’enzyme de conversion de l’angiotensine 2 chez les hommes et les femmes souffrant d’insuffisance cardiaque et effets des inhibiteurs de la rénine-angiotensine-aldostérone. Eur Heart J 2020; 41(19):1810-7

Li W, Moore MJ, Vasilieva N, Sui J, Wong SK et al. Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature 2003;426(6965):450–4.

Sharma G, Volgman AS, Michos ED. Sex differences in mortality from COVID-19 pandemic: are men vulnerable and women protected? JACC Case Rep 2020.

Chen N, Zhou M, Xuang D, Qu J Fengyun G et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet 2020;395:507-13.

Bouzid G et al. Rôle du système ABO et étude des facteurs prédictifs de mortalité dans l’infection à SARS-COV-2. MedrXiv 2020.

Gao Y, Li T, Han M,Xiuyong Li, Dong Wu et al. Diagnostic utility of clinical laboratory data determinations for patients with severe COVID19. Med Virol 2020 ; 92(7) :791-6. doi:

1002/jmv.25770

Wen Zhang, Chuanwei Li,Yu Xu, Binfeng He, Mingdong Hu,Guoqiang Cao et al. Hyperglycemia and Correlated High Levels of Inflammation Have a Positive Relationship with the Severity of Coronavirus Disease 2019. Mediators of Inflammation 2021 :881204 https://doi.org/10.1155/2021/8812304.

Yang L, Han Y,Nilsson-Payant BE, Gupta V, Wang P, et al. A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids. Cell Stem Cell. 2020 Jul 2 ;27(1):125-36.

ReiteM, RajanM,Gómez-BanoyN, LauJD, Gomez-EscobarLG, Alvarez-MulettAG et al. Hyperglycemia in Acute COVID-19 is Characterized by Adipose Tissue Dysfunction and Insulin Resistance.2021. doi: https://doi.org/10.1101/2021.03.21.21254072

Lu R., Zhao X., Li J ,Niu P, Yang B, et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet. 2020;395(10224):565-74. doi: 10.1016/S0140-6736(20)30251-8.

Yang JK., Feng Y, Yuan MY, FuHJ,WuetBY al. Plasma glucose levels and diabetes are independent predictors for mortality and morbidity in patients with SARS. Diabetic Medicine. 2006;23(6):623-28. doi: 10.1111/j.1464-5491.2006.01861.x

Umpierrez G. E., Isaacs S. D., Bazargan N., You X., Thaler L. M., Kitabchi A. E. Hyperglycemia: an independent marker of in-hospital mortality in patients with undiagnosed diabetes. The Journal of Clinical Endocrinology and Metabolism2002 ;87(3):978-82. doi: 10.1210/jcem.87.3.8341 ;

-Wojtusciszyn.A. Montpellier HbA1c trap. General review.

Downloads

Published

2021-11-30

How to Cite

Koloina, R. M. ., Harisolofo, R. F. ., Fenohasina, R., & Andry, R. (2021). Glycemia and HBA1c with Patients Infected by SARS COV-2 in a Biochemical Laboratory in 2020. International Journal For Research In Biology & Pharmacy, 7(11), 01–04. https://doi.org/10.53555/bp.v7i11.1886

Most read articles by the same author(s)