Influence of Hemolysis on the Analytical Performance of BS 300 in the Determination of 6 Enzymes

Authors

  • Ramaminiaina Manevarivo Eddy Medical Biology Student, Laboratory of Joseph Ravoahangy Andrianavalona University Hospital Antananarivo, Madagascar
  • Ranaivosoa Miora Koloina Biologist, Laboratory of Biochemistry of Joseph Ravoahangy Andrianavalona University Hospital Antananarivo, Madagascar
  • Rakotoniana Tinà Medical Biology Student, Laboratory of Joseph Ravoahangy Andrianavalona University Hospital Antananarivo, Madagascar
  • Rahajanirina Valdo Medical Biology Student, Laboratory of Joseph Raseta Befelatanana University Hospital Antananarivo, Madagascar
  • Rasamoelina Tahinamandranto Scientist, Centre d’Infectiologie Charles Mérieux, University of Antananarivo, Madagascar
  • Rakoto Alson Olivat Professor, Biological Haematology, Medical Biology Department of the Faculty of Medicine Antananarivo, Madagascar
  • Rasamindrakotroka Andry Professor, Immunology, Laboratory of Training and Research in Medical Biology, University of Antananarivo, Madagascar
  • Randriamanantany Zely Arivelo Professor of Immunology, National Center for Blood Transfusion Antananarivo, Madagascar

DOI:

https://doi.org/10.53555/bp.v6i2.1192

Keywords:

biochemistry, BS 300, enzymes, hemolysis, interference

Abstract

Hemolysis is a common source of error in the determination of a large number of biochemical blood parameters. The aim of this study is to determine the hemolysis influence on analytical performances of the BS 300 (Mindray®) on the dosage of 6 enzymes such as lipase, gammaglutamyl transferase, alkaline phosphatase, alanine transaminase, aspartate aminotransferase and lactate dehydrogenase.The secondary aim was to establish a reliable reporting for the clinicians in front of hemolysed samples for the enzymes dosage. To determine an influence of the hemolysis on the measure, the variation limit of 10 % was chosen. Gammaglutamyl transferase, and lipase were negatively influenced by the hemolysis. Alanine transaminase, aspartate aminotransferase and lactate dehydrogenase were positively influenced by the hemolysis.

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Published

2020-02-28

How to Cite

Eddy, R. M., Koloina, R. M. ., Tinà, R., Valdo, R. ., Tahinamandranto, R. ., Olivat, R. A., Andry, R. ., & Arivelo, R. Z. (2020). Influence of Hemolysis on the Analytical Performance of BS 300 in the Determination of 6 Enzymes. International Journal For Research In Biology & Pharmacy, 6(2), 02–12. https://doi.org/10.53555/bp.v6i2.1192

Issue

Vol. 6 No. 2 (2020): International Journal For Research In Biology & Pharmacy (ISSN: 2208-2093)

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