Vol 5 No 9 (2019): International Journal For Research In Biology & Pharmacy (ISSN: 2208-2093)
Articles

Investigated Lateral Sphincterotomy versus 2% Diltiazem Gel Local Application in the Treatment of Chronic Fissure in ANO

Associated Professor Dr Barat Gul Meherzai
Lecturers of General Surgery and Urology Department Nangarhar medical faculty.
Associated Professor Dr Gulaqa Sadat
Lecturers of General Surgery and Urology Department Nangarhar medical faculty.
Published September 1, 2019
Keywords
  • Anal fissure,
  • Chemical sphincterotomy,
  • Surgical sphincterotomy
How to Cite
, A. P. D. B. G. M., & Associated Professor Dr Gulaqa Sadat. (2019). Investigated Lateral Sphincterotomy versus 2% Diltiazem Gel Local Application in the Treatment of Chronic Fissure in ANO. International Journal For Research In Biology & Pharmacy (ISSN: 2208-2093), 5(9), 11-15. Retrieved from https://gnpublication.org/index.php/bp/article/view/1101

Abstract

An anal fissure is a split in the anoderm over the hypertrophied band of internal sphincter at the anal verge fissure is almost always located close to the midline of the anal canal; in men, 95% are near the posterior midline and 5% near the anterior midline, whereas in women, about 80% will be located posteriorly and 20% anteriorly.

In this study we compare symptomatic relief, healing and side effects of topical 2% Diltiazem gel and lateral internal sphincterotomy in the treatment of chronic fissure in ANO. 

In this prospective trial, 58 surgical out patients and/or admitted patients with chronic fissure in ANO was randomly divided into Group 1 (Diltiazem gel) and Group 2 (internal sphincterotomy) with 25 patients in each Group. Patients were followed up at weekly intervals for six consecutive weeks and biweekly for subsequent 3 months.

Fissure was completely healed in 85.45% of patients in Group 1 and in 96.60% in Group 2. The mean duration required for healing of fissure was 5.02 weeks in Group 1 and 3.8 weeks in Group 2. 65.00% patients were free from pain in Group 1 whereas 70.98 % patients were free from pain in Group 2. No patient had any side effects in either group.

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