Investigation of Thrombocytopenia in Patients of Malaria
DOI:
https://doi.org/10.53555/bp.v5i8.1083Keywords:
Malaria, Plasmodium falciparum, Plasmodium vivax, thrombocytopeniaAbstract
Protozoan parasites of the genus Plasmodium cause malaria, a devastating disease prevalent across tropical regions around the world. In the year 2016, more than 216 million clinical cases and 445,000 deaths were reported across 91 countries worldwide This scientific research has started and ended in the period of 2 years, conducted from 2/1/2018 to 5/8/2019 in the infectious wards/branches of the Nangarhar medical faculty’s. Materials and Methods: We conducted this study to find out the frequency and the degree of thrombocytopenia in patients with malaria. In our study, 180 patients with malaria positive were investigated with platelet count. Results: In the study group of 180 patients: 101 (56.11%) were positive for Plasmodium vivax, 70 (38.88%) were positive for P. falciparum and 9 (5.00%) had mixed infection with both P. vivax and P. falciparum. Out of 101 cases detected with vivax malaria, 77 cases had thrombocytopenia. Out of 70 cases detected with falciparum malaria, 54 cases had thrombocytopenia. Among 9 cases of mixed infection, 6 cases had thrombocytopenia. Conclusions: Presence of thrombocytopenia in a patient with acute febrile illness in the tropics increases the possibility of malaria. The above finding can have therapeutic implications in context of avoiding unnecessary platelet infusion in malaria patients.
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A. J. Rodríguez-Morales, E. Sánchez, M. Vargas et al., “Anemia and thrombocytopenia in children with Plasmodium vivax malaria,” Journal of Tropical Pediatrics, vol. 52, pp. 49–51, 2005.
Dayan and K. K., Punnath K., Chandrasekhar V., et al. Malaria prevalence in angaluru city area in the southwestern coastal region of India. Malaria Journal. 2017; 16(1) doi: 10.1186/s12936-017-2141-0
D. K. Kochar, G. S. Tanwar, P. C. Khatri et al., “Clinical features of children hospitalized with malaria: a study from Bikaner, Northwest India,” American Journal of Tropical Medicine and Hygiene, vol. 83, no. 5, pp. 981–989, 2010.
Faseela TS, Roche, Anita KB, Malli CS, Rai Y. Diagnostic value of platelet count in malaria. J Clin Diagn Res. 2011; 5:464–6.
Jadhav UM, Patkar VS, Kadam NN. Thrombocytopenia in malaria: Correlation with type and severity of malaria. J Assoc Physicians India. 2004;52:615–8.
Howes RE, Battle KE, Mendis KN, Smith DL, Cibulskis RE, Baird JK, et al. Global epidemiology of plasmodium vivax. Am J Trop Med Hyg. 2016;95:15–34. doi: 10.4269/ajtmh.16-0141.
Kakilaya B. S. Malaria in Mangaluru. Malaria site. 2017
Khan SJ, Khan FR, Usman M, Zahid S. Malaria can lead to thrombocytopenia. Rawal Med J. 2008;33:183–5.
Lacerda MV, Mourao MP, Alexandre MA, Siqueira AM, Magalhaes BM, Martinez-Espinosa FE, et al. Understanding the clinical spectrum of complicated Plasmodium vivax malaria: a systematic review on the contributions of the Brazilian literature. Malar J. 2012;11:12. doi: 10.1186/1475-2875-11-12.
McMorran BJ, Marshall VM, De Graaf C, Drysdale KE, Shabbar M, Smyth GK, et al. Platelets kill intraerythrocytic malarial parasites and mediate survival to infection. Science. 2009;323:797–800. doi: 10.1126/science.1166296.
McMorran BJ, Burgio G, Foote SJ. New insights into the protective power of platelets in malaria infection. Commun Integer Biol. 2013;6:e23653. doi: 10.4161/cib.23653.
Park A . (2016),Textbook of preventive and social medicin. 23th ed.M/s banarsidas bhanot publisher 1167 prem nagar jabalpur 482 001 (M.P.) INDIA. P.222.
Price RN, Tjitra E, Guerra CA, Yeung S, White NJ, Anstey NM. Vivax malaria: neglected and not benign. Am J Trop Med Hyg. 2007;77:79–87.
Price RN, Tjitra E, Guerra CA, Yeung S, White NJ, Anstey NM. Vivax malaria: neglected and not benign. Am J Trop Med Hyg. 2007;77:79–87.
Thapa R, Biswas B, Mallick D, Sardar S, Modak S. Childhood plasmodium vivax malaria with severe thrombocytopenia and bleeding manifestations. J Pediatr Hematol Oncol. 2009;31:758–759. DOI: 10.1097/MPH.0b013e3181b7eb12.
World Health Organization. World Malaria Reports. 2017 ed. Geneva; 2017.
WHO. Global Technical Strategy for Malaria 2016-2030. Geneva: World Health Organization; 2015.
WHO . Definitions: severe falciparum malaria. In: guidelines for the treatment of malaria. 3. Geneva: World Health Orgnization; 2015.
Wickramasinghe SN, Abdalla SH. Blood and bone marrow changes in malaria. Baillieres Best Pract Res Clin Haematol. 2000;13:277–99.
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