An Assessment of Quality of Life in Libyan Patients with Bronchial asthma: a Clinical Benefit in using most Desirable Inhaler Techniques

  • Fathi Mohamed Sherif Department of Pharmacology & Clinical Pharmacy, UoT, Tripoli, Libya
  • Walid Y. Tarsin University of Tripoli
  • Nabila A. Hshad University of Tripoli
  • Ishraq Elshamli Tripoli Medical Centre
  • Henry Chrystyn Plymouth University
Keywords: Asthma, COPD, MDI, Lung drug delivery, 2 Tone trainer, Libya

Abstract

Inhaled drug therapy remains the treatment option of choice for majority of patients with asthma. Asthma is a major chronic inflammatory disease of the respiratory tract. This study is designed to evaluate if the use of 2Tone helps patients maintain the correct inhalation technique after training and can improve their quality of life using AQLQ (Asthma quality of life questionnaire) and JMI (Jones morbidity index) questionnaires. AQLQ is a disease-specific health related quality of life tool which has good measurement properties and valid as an evaluative and a discriminative instrument. JMI is used as a simple and practical tool for asthma evaluation morbidity. 125 Libyan asthmatic patients from respiratory department outpatient of medical center (Tripoli) were included. Patients were divided into two groups; intervention and control. The intervention group was divided into those who were verbally trained about the MDI inhalation flow rate technique named verbal group (VT) and those called the 2Tone group (2T). Patients in the 2T group received the same verbal training as the VT group and were given 2Tone Trainer. The second visit for all patients was held six weeks later and each patient was assessed in the same manner as on the first visit. The patient was asked to fill in a self-administered AQLQ and answer questions from JMI. All patients in control group at both visits were inhaling at flow rate < 90 L/min with mean IFR of 66 L/min. Patients mean IFR in VT and 2T groups were less than 90 L/min at visit 2. Comparison of patient’s total AQLQ scores between visits shows no patients in group control group recorded statistical difference. In contrast, 17 patients (48.6%) in VT group and 30 patients (83.3%) in the 2T group recorded significant difference in AQLQ score between visits. Comparisons in morbidity between groups at visits shown that about half of patients in 2T group and 20% of patients in VT group were reduced in the severity category after counselling whereas in control group. There was almost no statistical different between visits. No difference between the patient’s perceptions of symptom control at visit 1 between the groups was observed but a significant difference at visit 2 was noted. Comparison between visits within each group showed that in 2T group patients’ perception of their asthma symptoms improved but did not change in the other two groups. A correlation was very strong between juniper questionnaire and JMI as studied by counselling group with significant association. This study shows that a high correlation between juniper questionnaire and JMI by counselling. This may be a reflection to use JMI as a quick tool to evaluate asthmatic patients to save time and increase patient compliance.

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Author Biographies

Fathi Mohamed Sherif, Department of Pharmacology & Clinical Pharmacy, UoT, Tripoli, Libya

Fathi Sherif is a professor of pharmacology and is currently a vice-dean of faculty of pharmacy, University of Tripoli, Libya. He received his PhD in medicinal pharmacology from faculty of Medicine, University of Uppsala, Sweden (1992) and postdoctoral training in neuroscience in Uppsala University. He won WHO award for the youngest medical researcher in 1995 from world health organization. He is a lecturer of pharmacology at department of pharmacology and clinical pharmacy since 1993 and held a position of head of the department and head of postgraduate office at the university. Head of research unit at National Medical Research Center of ethno-pharmacology (traditionally used of medicinal plants and their potential actions on the CNS using animal behavioral models). A long-term involve in neuropsycho-pharmacology (GABA & MAO systems) in patients as well as long interest in animal behavioral pharmacology. He published several articles about the role of inhibitory transmitters in neuropsychiatric disorders. He supervising several postgraduate students in the area of clinical and basic pharmacology leading to M.Ph. He is a referee of several international journals and an editor in chief of Libyan J Med Res (ISSN 2312-5365) for the last five years and Pharmacy and Pharmacology International Journal (ISS 2373-6367).

Walid Y. Tarsin, University of Tripoli

Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, University of Tripoli, Tripoli, Libya

Nabila A. Hshad, University of Tripoli

Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, University of Tripoli, Tripoli, Libya

Ishraq Elshamli, Tripoli Medical Centre

Department of Respiratory, Tripoli Medical Centre, Tripoli, Libya.

Henry Chrystyn, Plymouth University

Inhalation Consultancy Ltd, Yeadon, Leeds and Faculty of Human and Health Sciences, Plymouth University, Plymouth, United Kingdom

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Published
2019-06-30
How to Cite
Sherif, F. M., Walid Y. Tarsin, Nabila A. Hshad, Ishraq Elshamli, & Henry Chrystyn. (2019). An Assessment of Quality of Life in Libyan Patients with Bronchial asthma: a Clinical Benefit in using most Desirable Inhaler Techniques. International Journal For Research In Biology & Pharmacy (ISSN: 2208-2093), 5(6), 01-13. Retrieved from https://gnpublication.org/index.php/bp/article/view/949