UTERINE CARCINOSARCOMA: A CASE REPORT


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Authors

  • Nomenjanahary Lalaina Depatment of Pathology, Joseph Ravoahangy Andrianavalona University Hospital, Antananrivo, Madagascar
  • Ambriambelo Zinambatosoa Andrianina Depatment of Pathology,Soavinandriana Hospital, Antananrivo, Madagascar
  • Raivoherivony Zo Irène Depatment of Pathology, Joseph Ravoahangy Andrianavalona University Hospital, Antananrivo, Madagasca
  • Randrianjafisamindrakotroka Nantenaina Soa Chairman of the Department of Pathology, Medical School of Antananarivo, Madagascar

DOI:

https://doi.org/10.53555/bp.v12i2.2610

Keywords:

Uterine carcinosarcoma, malignant mixed müllerian tumor, pathology, endometrial cancer

Abstract

Uterine carcinosarcoma, also known as malignant mixed müllerian tumor, is a rare and highly aggressive endometrial malignancy, accounting for 3–5% of uterine cancers. It is characterized by a biphasic proliferation composed of carcinomatous and sarcomatous components and is associated with poor prognosis. We report the case of a 67-year-old postmenopausal woman presenting with abnormal uterine bleeding for six months. Clinical examination and imaging revealed a cervico-uterine mass. Total hysterectomy with bilateral salpingo-oophorectomy was performed. Histopathological examination showed a biphasic tumor with deep myometrial invasion, lymphovascular emboli, and extension to the parametrium, left fallopian tube, and right ovary. The diagnosis of uterine carcinosarcoma, FIGO stage IIIA (pT3Nx), was established. Uterine carcinosarcomas typically occur in postmenopausal women and commonly present with abnormal uterine bleeding. Recent morphological, immunohistochemical, and molecular data support a monoclonal epithelial origin with secondary sarcomatous differentiation. The epithelial high-grade component is the main determinant of prognosis. Uterine carcinosarcoma is a rare but aggressive tumor, frequently diagnosed at an advanced stage. Pathological examination plays a pivotal role in diagnosis and prognostic assessment, guiding therapeutic management.

 

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Published

2026-07-18

How to Cite

Nomenjanahary Lalaina, Ambriambelo Zinambatosoa Andrianina, Raivoherivony Zo Irène, & Randrianjafisamindrakotroka Nantenaina Soa. (2026). UTERINE CARCINOSARCOMA: A CASE REPORT. International Journal For Research In Biology & Pharmacy, 12(2), 18–21. https://doi.org/10.53555/bp.v12i2.2610

Issue

Vol. 12 No. 2 (2026): International Journal For Research In Biology & Pharmacy (ISSN: 2208-2093)

Section

Articles

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