HODGKIN DISEASE IN CHILDREN : BICENTRIC STUDY
DOI:
https://doi.org/10.53555/bp.v10i1.2381Abstract
Hodgkin disease is a rare tumor within the pediatric population, exhibiting a higher incidence in developing countries
such as Madagascar. The objective of this study was to elucidate the epidemiological and anatomopathological
characteristics of Hodgkin’s disease in the pediatric population of Madagascar.
A retrospective analysis was conducted,focusing on the description of Hodgkin’s lymphoma diagnosed in children aged
0 to 15 years over five year intervals, spanning from january to december 2018. The data were sourced from the
Pathological Anatomy and Cytology laboratories of the CHU-JRA and SALFA Andohalo.
Through out the study period, a total of 32 cases of Hodgkin’s lymphoma in children were identified, constituting
43.24% of the diagnosed lymphoma cases during this period. The age of the patients ranged from 3 to 15 years, with an
average age of 9.28 years. A notable male predominance was observed, with a sex ratio of 2.2. In all cases, the location
was cervical region. The histological subtype revealed a predominance of the sclero-nodular variant in 69% of cases.
Our findings indicate a relatively higher prevalence of Hodgkin’s deseasein our study compared to other developing
countries. It affected younger children in more than half cases, with a male predominance.
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Dorffel W, Luders H et al. Preliminary results of the multicenter trial GPOH-HD 95 for the treatment of Hodgkin’s disease in children and adolescents : analysis and out look. Klein Padiatr 2003 ; 215(3) : 139 – 145
Parkin M, Nectoux j, Stiller C, Draper G. The incidence of childhood cancers worldwide. Pediatrics 1989 ; 44 :725-36
EssisLorng JC. Hodgkin's disease in black African children: epidemiological, clinical, paraclinical and evolving aspects (Experience of the clinical hematology department of Yopougon University Hospital). Thèse 2003.
Cadvar AO, Goozdasoglu S, Yavuz G, et al. Characteristics of « early type-I pattern » (0-6 years) Hodgkin’s disease in Turkish children. Turk J Haematol 2002 ;19 :55-62.
Haluska FG, Brufsky AM et al. The cellular biology of the Reed-Sternberg cell. Blood 1994 ; 84 : 1005-19
Khanfir A, Toumi N et al. Hodgkin's disease in children in southern Tunisia: study of 23 cases; Cancer/ Radiotherapy 11 (2007) 241 – 246
Shankar AG, Ashley S, Radford M, Barrett A, Wright D, Pinkerton CR. Does histology influence outcome in childhood Hodgkin’s disease ? Results from United Kingdom Children’s Cancer Study Group. J Clin Oncol 1997 ; 15 :2622-30
Alebouyeh M, Vossough P. Hodgkin disease in Iranian children. EurJPediatr 1993 ;152 :22 - 3
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