Solubility Enhancement of Poorly Soluble Drug Simvastatin by Solid Dispersion Technique
DOI:
https://doi.org/10.53555/bp.v2i1.147Keywords:
Simvastatin,, kneading, solid dispersions,, SSG, carrierAbstract
The objective of the present study was to formulate solid dispersions (SDs) of Simvastatin (SIM) to improve the aqueous solubility, dissolution rate & to facilitate faster onset of action. Simvastatin is a BCS class II drug having low solubility & therefore low oral bioavailability. In the present study, SDs of Simvastatin different drug-carrier ratios was prepared by kneading method. The results showed that Simvastatin solubility & dissolution rate was enhanced with polymer SSG in the ratio 1:7 due to increase in wetting property (or) may be due to change in crystallinity of the drug.
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References
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