Biological Importance of Ascorbic Acid(VitaminC) in Human Health: A Classic Review

Authors

  • K. N. Dave Associate Professor, Biochemistry Department, LTMM-College, Sion, Mumbai- 400 022
  • R. S. Patil Laboratory Technician, Biochemistry Department, HBTM College & Dr. R. N. Cooper Mun. Gen. Hospital, Vileparle

DOI:

https://doi.org/10.53555/bp.v3i7.127

Keywords:

Ascorbic acid (Vitamin C), biological significance, human health

Abstract

The recognition of vitamin C (Ascorbic acid) is associated with history of an unrelenting search for the
cause of the ancient hemorrhagic disease scurvy. Isolated in 1928, vitamin C is essential for the development and maintenance of connective tissues. It plays an important role in bone formation, wound healing and the maintenance of healthy gums. Vitamin C plays an important role in a number of metabolic functions including the activation of the B vitamin, folic acid, the conversion of cholesterol to bile acids and the conversion of the amino acid, tryptophan, to the neurotransmitter, serotonin. It is an antioxidant that protects body from free radicals' damages. It is used as therapeutic agent in many diseases and disorders. Vitamin C protects the immune system, reduces the severity of allergic reactions and helps fight off infections.

Downloads

Download data is not yet available.

References

Anderson,R.andP.T.Lukey,1987.Abiologicalroleforascorbateintheselectiveneutralizationofextracellularphagocyte-derivedoxidants.Annals of the NewYorkAcademyof Sciences,498:229-247.

Axelrod,D.R.,1985.AscorbicacidandurinarypH.JAMA, 254:1310.

Baur,H.andH.Staub,1954.Treatmentofhepatitiswithinfusionsofascorbicacid:Comparisonwithothertherapies.JAMA,156:565.

Bendich,A., 1990. "Antioxidant micronutrients andimmuneresponses".In:Bendich,A.andChandra,R.K. (eds.). Micronutrientsand immunefunctions.N.Y.AcademyofSciences,N.Y,pp:175.

Block,G.,1991.EpidemiologicevidenceregardingvitaminCandcancer.Am.J.Clin.Nutr.,54:1310S-1314

S.Block,G.,1992.Thedatasupportaroleforantioxidantsinreducingcancerrisk.Nutr.Res.,50:207-213.

Bobyrev,V.N.,I.Sh.VeselskilandL.E.Bobyreva,1989.Antioxidants inthepreventionandtreatmentofcerebralarteriosclerosis,Zh.Nevrapatol. Psikltatr.,89:60-63.

Boyd,H.,1995.EyepressureloweringeffectofvitaminC.J.OrthomolecularMed.,10:165-168.

Briggs,M.H.,1984.VitaminCandinfectiousdisease:areviewoftheliteratureandtheresultsofarandomized,prospectivestudyover8years.InXHBriggsXH,(Eds).RecentVitamin Research.BocaRaton,FL:CRCPress,pp:39-82s.

Bruemmer,B.,1996.Nutrient intake inrelation to bladder cancer among middle aged men and women. Am. J. Epidemic.,144:485-495.

Brzozovvski,T.,S.Kwiecie&nacute,P.C.Konturek,S.J.Konturek,M.Mitis-Musiol,A.Duda,Biela&nacute,W.SkiandE.G.Hahn,2001. MedSci.Monit,7(4):592-599.

Burns,(1959).J.J.Am.J.Med.,26:740.Cathcart,RF.,1984.VitaminCinthetreatmentofacquiredimmunedeficiencysyndrome(AIDS).Med.Hypotheses, 14:423-433.

Cunningham,J.J.,S.L.EllisandK.L.McVeigh,1991."Reducedmononuclearleukocyteascorbicacidcontentinadultswithinsulin dependentdiabetesmellitusconsumingadequatedietaryvitaminC".Metabolism,40:146-149.

Dason,E.B.,WAHarrisandWAPowell,1990.Relationshipbetweenascorbicacidandmalefertility.In:AspectsofSomeVitamins,MineralsandEnzymesinHealthandDisease,de.GHBourne.WorldRev.Nutr.Diet,62:1-26.

Davis,R.H.,1990.VitaminCinfluenceonlocalizedadjuvantarthritis.J.An.Podiatr.Med.Assoc.,80: 414-8.

Dawson,E.B.,WA.Harris,M.C.TeterandL.C.Powell,1992.Effectofascorbicacidsupplementationonthe spermqualityofsmokers.FertileSterile,58:1034-1039.

Dekkers,J.C.,L.J.VanDoornenandH.C.Kemper, 1996.Theroleofantioxidantvitaminsand enzymesinthe preventionofexercise-inducedmuscledamage.SportsMed.,21:213-238.

Douglas,RM.,E.B.ChalderandTreacy,2001.VitaminCforpreventingandtreatingthecommoncold(CochraceREview).In:TheCochraneLibrary.Oxford:UpdateSoftware.Enstrom,E.J.,1992.VitaminCintakeandmortalityamong asample oftheUnitedStatespopulation.Epidemiology,3:194-202.

Feiz,H.R.andS.Mobarhan,2002.Nutr.Rev.,60:346.

Ferraroni,M.,1994.Selectedmicronutrientintakeandtheriskofcolorectal cancer.Br.J.Cancer,70:1150-1155.

Fraga,C.G..PAMotchnikandMKShigenaga.1991.Ascorbicacidprotects againstendogenousoxidativeDNAdamageinhumansperm. Proc.Natl.Acad.Sci.,88:11003-11006.

Frei,B.,1991.Ascorbicacidprotectslipidsinhumanplasmaand Low-Density Lipoprotein againstoxidativedamage.Am.J.Clin.Nutr..54:1113S-1118S.

Frei,B.,1994.Reactiveoxygenspeciesandantioxidantvitamins:mechanismsofaction. Am.J.Med.,97:5S-13S.

Gale,R.C.,1995.VitaminCandriskofdeathfromstrokeandcoronaryheartdiseaseincohortofelderlypeople.Br.Med.J.,310:1563-1566.

Hankinson,E.S.,1992.Nutrientintakeandcataractextractioninwomen:Aprospectivestudy.Br.Med.J.,305:35-39.

Hatch,E.G..1995.Asthma.inhaledoxidantsanddietaryantioxidants.Am.J.Clin.Nutr..61:625S-630S.

Heitzer,T.,1996.AntioxidantvitaminC improvesendothelialdysfunctioninchronicsmokers.Circulation.94:6-9.

Hemila,H..1992.VitaminCandthecommoncold.Br.J.Nutr..67:3-16.

Hemila,H..1997.VitaminCintakeandsusceptibilitytothecommoncold.Br.J.Nutr..77:59-72.

Jacobs,M.M.,1993.Diet,nutritionandcancerresearch:AnOverview.NutritionToday.19-23.

Jacques,P.F..L.T.Chylack.R.B.McGandyandS.C.Hartz,1988.Antioxidantstatusinpersonswithandwithoutsenilecataract.ArchOphthalmol.106:337-340.

Jacques,P.F.andL.T.Jr.Chylack.1991.Epidemiologicevidenceofarolefortheantioxidantvitaminsandcarotenoidsincataractprevention.Am.J. Clin.Nutr.,53:352S-355S.

Jialal,I..1990.Vega.GloriaLenaandGrundy.Scott.M."PhysiologiclevelsofascorbateinhibittheoxidativemodificationsofLowDensityLipoproteins,"Atherosclerosis.82:185.

Joel,A..Simon.SHEstherandA.T.Jeffrey.2001.RelationofserumascorbicacidtomortalityamongUSadults.J.Am.CollegeofNutr..20(3).Johnson,C..1993.Am.J.Clin.Nutr..8:103-105.

Kallner,A.B..D.HartmannandDHHorning.1979.Steadystateturnoverandbodypoolofascorbicacidinman.Am.J.Clin.Nutr..32:530-539.

Kinsman,RAandJ.Hood.1971.Somebehavioraleffectsofascorbicaciddeficiency.Am.J.Clin.Nutr.,24:455.

Klenner,F.R..1949.ThetreatmentofpoliomyelitisandothervirusdiseaseswithvitaminC.J.SouthernMed. Surg..111:210-214.

Knodell,R.G..MATate.B.F.AkiandJ.WMlson.1981.VitaminCprophylaxisforpost-transfusionhepatitis:lackofeffectinacontrolledtrial.Am.J.Clin.Nutr..34:20-23.

Kuvshinnikov,VA. 1989.""UseoftheantioxidantcomplexofvitaminsA,EandCinmurineleukemia,"Gematol.Transvuziol..34:23-28.

Lehr,Hans-Anton.1995.Protection fromOxidizedLDL-lnducedLeukocyteAdhesiontoMicrovascularandMacrovascularEndotheliumIn-VivobyVitaminCbutnotbyVitaminE.Circulation.91:1525-1532.

Levine,N.G.,1996.Ascorbicacidreversesendothelialvasomotordysfunctioninpatientsvvithcoronaryarterydisease.Circulation.93:1107-1113.

Losonczy.GK.1996.VitaminEandvitaminC supplementuseandriskofall-causeandcoronary heartdiseasemortalityinolderpersons.Am.J.Clin.Nutr..64:190-196.

Lunec,J.B..1985.Thedeterminationofdehydroascorbicacidandascorbicacidinthe serumandsynovialfluidofpatientswithrheumatoidarthritis.FreeRadicalResearchCommunications,1:31-39.

Malins,C.D., 1996. Progression of human breastcancerstothemetastaticstateislinkedtohydroxylradical-induced DNAdamage. Proceedingsofthe NationalAcademyofSciencesUSA.93:2557-2563.

Monsen,E.R., 1978.Estimationofavailabledietaryiron.Am.J.Clin.Nutr..31:134.

Olson,JAandR.E.Hodges.1987.Recommendeddietaryintakes(ROI)ofvitaminCinhumans.Am.J.Clin.Nutr..45:693-703.

Palmquist, B..B.PhillipsonandP.Barr.1984.Nuclearcataractandmyopiaduringhyperbaricoxygentherapy.Br.J.Ophthalmol..68:113-117.

Piesse,J.W.,1985.NutritionalfactorsincalciumcontainingkidneystoneswithparticularemphasisonvitaminC.IntClin.Nutr.Rev..5:110-129.

Rath,M..1993.Eradicating heartdisease. HealthNow.SanFrancisco,CA.Renker,K.andS.Wegner.1954.VitaminC-ProphylaxeinderVolkswertfStralsund.DeutscheGesundheitswesen.9:702-706.

Sahyoun,R.N..1996.Carotenoids.vitamins CandEandmortalityinanelderlypopulation.Am.J.Epidemic..144:501-511.

Shult,PAandE.C.Dick.1990.ProceedingsofthelnerscienceConferenceofAntimicrobialAgentsandChemotherapy.Atlanta.Sies,H.andS.Mlhelm.1995.VitaminsEandC.beta-caroteneand othercarotenoidsasantioxidants.Am.J.Clin.Nutr..62:1315S-1321S.

Sinclair,A.J..A.J. Girling and L. Gray. 1992. Aninvestigationoftherelationshipbetween freeradicalactivityandvitaminCmetabolisminelderlydiabeticsubjectswithretinopathy.Gerontology.38:268-274.

Stein,H.B.,1976.Ascorbicacid-induceduricosuria:aconsequenceofmegavitamintherapy.Ann. Intern.Med..84:385-388.

Taylor,A.,1993.Cataract:relationshipbetweennutritionandoxidation.J.Am.Coll.Nutr..12:138-146.

Taylor,A..P.F.JacquesandD.Nadler.1991.Relationshipinhumansbetweenascorbicacidconsumptionandlevelsoftotalandreduceascorbicacidinlens,aqueoushumorandplasma.Curr.Eye.Res..10:751-759.

Taylor,T.V..1974.Ascorbicacid supplementationinthe treatmentofpressure-sores.TheLancet,544-546.

Thurnham,D.I..2000.Water-SolubleVitamins(VitaminCandBVitamins,Thiamin,Riboflavin andNiacin).In"HumanNutritionandDietetics".Garrow,J.S.,W.P.T.James.A.Ralph(Eds.).Churchill.LivingstonPublishers.EdinburghLondon.249-257.

Tomoda,H..1996.Possiblepreventionofpost-angioplastyrestenosisbyascorbicacid.Am.J.Cardiology.78:1284-1286.

Trout,D.L.,1991.VitaminCandcardiovascularrisksfactors.Am.J.Clin.Nutr..53:322S-325S.

Uddin,S.andA.Sarfraz.1995.Antioxidantsprotectionagainstcancerandotherhumandiseases.ComprehensiveTherapy.21:41-45

Vasil'ev,V.S.,V.I.KomarandN.I.Kisel.1989.HumoralandcellularindicesofnonspecificresistanceinviralhepatitisAandascorbicacid.Ter-Arkh..11:119-129.

Voelker,R.,1994.Recommendationsforantioxidants:Howmuchevidenceisenough?J.Am.Med.Assoc.,271: 1148-1149.

Wandzilak,T.R.. S.D.D"Andre.PADavisandH.E.Williams.1994.EffectofhighdosevitaminConurinaryoxalatelevels.J.Ural.. 151:834-837.

Weber,C.,1996.Increasedadhesivenessofisolatedmonocytestoendotheliumispreventedbyvitamincintakeinsmokers.Circulation.93:1488-1492.

Whitaker,M.J.,1985.ReversingHeart Disease.Warner Books.NY.

Will,J.C.andT.Tyers.1996.Doesdiabetes mellitusincreasetherequirementforvitaminC?Nutr.Rev.,54:193-202.

Woodhouse,P.R.andKhaw.KayTee.1994.SeasonalvariationsinvitaminCstatus,infection,fibrinogenandcardiovasculardisease-Aretheylinked?AgeandAging.23:5.

Downloads

Published

2017-07-31

How to Cite

Dave, K. N., & Patil, R. S. (2017). Biological Importance of Ascorbic Acid(VitaminC) in Human Health: A Classic Review. International Journal For Research In Biology & Pharmacy, 3(7), 01–08. https://doi.org/10.53555/bp.v3i7.127

Issue

Vol. 3 No. 7 (2017): International Journal For Research In Biology & Pharmacy

Section

Articles

License

Copyright (c) 2017 gnpublication@

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

In consideration of the journal, Green Publication taking action in reviewing and editing our manuscript, the authors undersigned hereby transfer, assign, or otherwise convey all copyright ownership to the Editorial Office of the Green Publication in the event that such work is published in the journal. Such conveyance covers any product that may derive from the published journal, whether print or electronic. Green Publication shall have the right to register copyright to the Article in its name as claimant, whether separately
or as part of the journal issue or other medium in which the Article is included.

By signing this Agreement, the author(s), and in the case of a Work Made For Hire, the employer, jointly and severally represent and warrant that the Article is original with the author(s) and does not infringe any copyright or violate any other right of any third parties, and that the Article has not been published elsewhere, and is not being considered for publication elsewhere in any form, except as provided herein. Each author’s signature should appear below. The signing author(s) (and, in