Verification of the Zinc Oxide Assay Method in Simanovsky Ointment for its Chemical Stability Estimation

Authors

  • L. P. Savchenko Department of Quality, Standardization and Certification of Medicines Institute of Pharmacy Professionals Qualification Improvement, National University of Pharmacy, Kharkiv, Ukraine
  • K. A. Uminska Department of Quality, Standardization and Certification of Medicines Institute of Pharmacy Professionals Qualification Improvement, National University of Pharmacy, Kharkiv, Ukraine
  • V. A. Georgiyants Department of Pharmaceutical Chemistry, National University of Pharmacy, Kharkiv, Ukraine

DOI:

https://doi.org/10.53555/bp.v4i3.124

Keywords:

compounding ointment, zinc oxide, complexometric titration, verification

Abstract

Stability is the main quality parameter of any medicine. The literature contains a large number of methods for the known active ingredients analysis, but often there is no information about their use in the separate dosage forms analysis. The Simanovsky ointment often is being prepared in pharmacies of Ukraine. One of its main active ingredient is zinc oxide. Verification of the zinc oxide assay method in the medicine composition was done for proving the possibility of its use for the ointment chemical stability analysis.Optimal approach to ointment sample preparation was chosen. The complexometry method was used for the zinc oxide assay in the ointment. The obtained values of all method validation parameters don’t exceed the permissible criteria. The requirements for accuracy (δ,%=0.51≤1.02) and precision (∆Z=1.13≤3.20) are fulfilled. The method was tested on the ointment samples. Obtained RSD value (RSD=0.37 %) proves the good reproducibility of the results.

Downloads

Download data is not yet available.

References

Bajaj, S., Singla, D., Sakhuja, N. (2012). Stability testing of pharmaceutical products. Journal of Applied Pharmaceutical Science, 02 (03), 129–138.

Kopp,S. (2006). Stability testing of pharmaceutical products in global environment. RAJ Pharma,May, 291-294.

Allen, V. L. Compounding, stability and beyond-usedates. Secundum artem, 7 (3). Available at: http://www.perrigo.com/business/pdfs/Sec%20Artem%207.3.pdf.

Panda, A., Kulkarni, S., Tiwari, R. (2013). Stability studies: an integral part of drug development process. International Journal of Pharmaceutical Research and Bio-Science, 2 (6), 69–80.

State Pharmacopoeia of Ukraine: at3 volumes. 2-nd ed.Vol. 1(2015).Kharkiv: State enterprise “Ukrainian scientific pharmacopoeial center of medicines quality”,1128.

State Pharmacopoeia of Ukraine: at 3 volumes. 2-nd ed.Vol. 2(2014). Kharkiv: State enterprise “Ukrainian scientific pharmacopoeial center of medicines quality”, 724.

European Pharmacopoeia. 8th ed. Vol. 2(2013). Strasbourg: European Directorate for the Quality of Medicines & HealthCare of the Council of Europe, p.3594.

The United States Pharmacopoeia. (2008). Rockville:The United States Pharmacopeial Convention, 32-NF 27.

Downloads

Published

2018-03-31

How to Cite

Savchenko, L. P., Uminska, K. A., & Georgiyants, V. A. (2018). Verification of the Zinc Oxide Assay Method in Simanovsky Ointment for its Chemical Stability Estimation. International Journal For Research In Biology & Pharmacy, 4(3), 23–31. https://doi.org/10.53555/bp.v4i3.124

Issue

Vol. 4 No. 3 (2018): International Journal For Research In Biology & Pharmacy

Section

Articles

License

Copyright (c) 2018 International Journal For Research In Biology & Pharmacy

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

In consideration of the journal, Green Publication taking action in reviewing and editing our manuscript, the authors undersigned hereby transfer, assign, or otherwise convey all copyright ownership to the Editorial Office of the Green Publication in the event that such work is published in the journal. Such conveyance covers any product that may derive from the published journal, whether print or electronic. Green Publication shall have the right to register copyright to the Article in its name as claimant, whether separately
or as part of the journal issue or other medium in which the Article is included.

By signing this Agreement, the author(s), and in the case of a Work Made For Hire, the employer, jointly and severally represent and warrant that the Article is original with the author(s) and does not infringe any copyright or violate any other right of any third parties, and that the Article has not been published elsewhere, and is not being considered for publication elsewhere in any form, except as provided herein. Each author’s signature should appear below. The signing author(s) (and, in