Study of Lipid Profile in Non-diabetic Ischemic heart Disease Patients in Jalalabad, Afghanistan

  • Dr. M. Azim Azimee Nangarhar Medical Faculty
  • Dr. Abdul Ghafar Sherzad
Keywords: Lipid profile, Cronary heart disease, Dyslipidemia

Abstract

Coronary artery disease is leading cause of morbidity and mortality in both developing and developed countries.  This cross sectional analytic   study was conducted in Nangarhar university Teaching hospital in 2017 June to 2018 July , was undertaken to study dyslipidemia among the patients admitted to hospital with coronary artery disease. 111 subsequent cases diagnosed as coronary artery disease 49 were male (44.1%) and 62(55.9%) female age range 38-80 years. Age, sex, Blood pressure, History of smoking and Body Mass Index were recorded in each subject in standard questioner. Blood samples for investigations of lipid profile i.e. serum cholesterol (CHO), Triglyceride (TG), High Density Lipoprotein– cholesterol (HDL-C) and Low Density Lipoprotein-cholesterol (LDL-C) were collected from Patients. In study 87(78.37% were Have hypertension and 84(75.7 %) had family history of hypertension. It was found that LDL (Mean±SD) (92.47±17.50), HDL (40.44±6.90) and TG high level (193.46±40.83) and total cholesterol (175.55±31.43). 62(55.9%) has positive family history of Diabetes mellitus, 87(78.37%) History of Hypertension, and it was found that High prevalence of Dyslipidemia (hypercholesterolemia, Hypertriglyceridemia and Low HDL) were significantly in all age groups.13.46% normal weight, 76.57% were overweight and 23.42% are obese.

Downloads

Download data is not yet available.

Author Biographies

Dr. M. Azim Azimee, Nangarhar Medical Faculty

Lecturers of Biochemistry Department, Nangarhar Medical Faculty

Dr. Abdul Ghafar Sherzad

Lecturers of Biochemistry Department, Nangarhar Medical Faculty.

References

Newby DE, Grubb NR, Bradbury A. Cardio Vascular Disease. NR College, BR Walker, SHR Alston (Eds). (2010), Davidson's Principles & Practice of Medicine; 21st edition, Churchill Livingstone Elsevier Limited New Delhi, Pp. 577-579.

Brown DA, Breit SN. (06/06/2002); CRP and Vascular Risk. Syd path; Available from:http://www.sydpath.stvincent.com.au/ tests/ CRP Risk. Html

Ridker PM, Glynn RJ, Hennekens CH. C-Reactive Protein Adds to the Predictive Value of Total and HDL Cholesterol in Determining Risk of First Myocardial Infarction. Circulation 1998; 97: 2007- 2011.

Ridker PM, Rifai N, Rose L, Buring JE, Cook NR. Comparison of C - reactive protein and Low Density Lipoprotein Cholesterol Levels in the Prediction of First Cardiovascular Events. N Eng J Med 2002; 347: 1557-1565.

Lopez AD, Murray CC. The global burden of disease, 1990-2020. Nat Med 1998; 4:1241-3.

Murray CJL, Lopez AD. The global burden of disease: a comprehensive assessment of mortality and disability from disease, injuries and risk factors in 1990 and projected to 2020. Boston (Mass): Harvard School of Health; 1996.

The World Health Report 1999: The double burden: Emerging epidemics and persistent problems. WHO 1999. Available at: <http://www.who.org>.

World Health Statistics 2008: WHO. Available at: .

Beaglehole R. International trends in coronary heart disease mortality and incidence rates. J Cardiovascular Risk 1999; 6:63–8.

Okrainec K, Banerjee DK, Einsenberg MJ. Coronary artery disease in the developing world. Am Heart J 2004; 148:7–15.

Yusuf S, Hawken S, Ounpuu S, Dans T, Avezum A, Lanas F, et al. INTERHEART study investigators. Effects of potentially modifiable risk factors associated with myocardial infarction in 52 countries (The INTERHEART Study) case-control study. Lancet2004; 364:937–42.

Johnson CL, Rifkind BM, Sempos CT, Carroll MD, Bachorik PS, Briefel RR, et al. declining serum total cholesterol levels among US adults. The National Health and Nutrition Examination Surveys. JAMA. 1993; 269(23):3002–8.

Reddy KS, Yusuf S. Emerging epidemic of cardiovascular disease in developing countries. Circulation 1998; 97:596-601.

Mohan V, Sandeep S, Deepa R, Shah B, Varghese C. Epidemiology of type 2 diabetes: Indian scenario. Indian J Med Res 2007; 125:217-30.

Biorch, G., Blomquist, G. and Sievers, J. (1957) Cholesterol values in patients with myocardial infarction and normal control group. Acta. Med. Scand. 156,493-497.

Tibblin, G. and Cramer, K. (1963) Serum lipids during the course of acute myocardial infarction and one year afterwards Acta Med. Scand. 174,451-455.

Avogaro, A., Bittilin Bon, G., Cazzalato, C. Quinci, G.B., Sanson, A., Sparla, H. and Zagatti, G.C. (1978). Variations in Apo lipoproteins B and A during the course of myocardial infarction. Eur. J. Clin. Invest. 8,121-129.

Ryder, R.E.J., Hayes, T.M., Mulligan, I.P., Kingwood, J.C., Williams, S. and Owens, D.R.(1984) How soon after myocardial infarction should plasma lipid values be assessed ? Br.Med. J. 289, 1651-1653..

Jackson, R., Scragg, R., Marshall, R, White, O’Brien, K. and Small, C. (1987) Changes is serum lipid concentrations during first 24, hours after myocardial infarction. Br. Med. J. 294, 1588-1589.

Heldenburg, D., Rubenstein, A., Levtov, 0., Berns, L., Werbin, B. and Tamir, L. (1980) Serum lipids and lipoprotein concentrations during the acute phase of myocardial infarction. Atherosclerosis 35,433-437.

Swedarsen, M., Vythilingum, S. Jalal, I. and Nadar, R. (1988). Plasma lipids can be reliably assessed within 24 hours after acute myocardial infarction. Postgrad. Med. J. 64, 352-356.

Buckley, B.M. and Bold, A.M. (1982) Managing hyperlipidaemias, Br. Med. J. 285, 1293-1294.

Schlant, R.C. and Digirolamo, M. (1978) Modification of risk factor in the prevention and management of coronary atherosclerotic heart disease: The Heart, 4th Ed., Hurst J.W., Logue R.B., Schlant R.C., Wenger N.K., New York: McGraw Hill Book Co., p 1311-1344.

Friedwald, W.T., Levy, R.I. and Fredrickson, D.S.,(1972) Estimation of the concentration of low density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge. Clin. Chem. 18, 499-502.

Jelovesk FR. Cholesterol and Lipid Disorders. Women's Diagnostic Cyber; 1997; Available from: http://www.wedxcyber.com/ngen 15.htm, 6 July 2004.

. Jain P, Bhandari S, Siddhu A. A case control study of risk factors for coronary heart disease in urban Indian middle aged males. Indian Heart J 2008; 60:233-40.

Enas EA, Garg A, Davidson MA, Nair VM, Huet BA, Yusuf S. Coronary heart disease and its risk factors in first-generation immigrant Asian Indians to the United States of America. Indian Heart J 1996; 48:343-53.

Enas EA, Yusuf S, Sharma S. Coronary artery disease in South Asians. Second meeting of the International Working Group. 16March 1997, Anaheim, California. Indian Heart J 1998; 50:105-13.

Maitra A, Shanker J, Dash D, John S, Sannappa PR, Rao VS, et al. Polymorphisms in the IL6 gene in Asian Indian families with premature coronary artery disease – The Indian Atherosclerosis Research Study. Thromb Haemost 2008; 99:944-50.

Chodorowski Z, Anand JS, Foerster J, Gruchaa M, Chlebus Differences in lipid profile in patients with first myocardial infarction occurring at different ages. Borgis – New Medicine 2004; 2:48–51.

Kronmal RA, Cain KC, Ye Z, Omenn GS. Total serum cholesterol levels and mortality risk as a function of age. A report based on the Framingham data. Arch Intern Med 1993; 153:1065–73.

Krumholz HM, Seeman TE, Merrill SS, Mendes de Leon CF, Vaccarino V, Silverman DI, et al. Lack of association between cholesterol and coronary heart disease mortality and morbidity and all-cause mortality in persons older than 70 years. JAMA 1994; 272(17):133540.

Thompson PD, Buchner D, Pina IL, Balady GJ, Williams MA, Marcus BH, et al. Circulation 2003;107:3109-16.

Published
2019-07-28
How to Cite
Dr. M. Azim Azimee, & Dr. Abdul Ghafar Sherzad. (2019). Study of Lipid Profile in Non-diabetic Ischemic heart Disease Patients in Jalalabad, Afghanistan . International Journal For Research In Biology & Pharmacy (ISSN: 2208-2093), 5(7), 26-34. Retrieved from https://gnpublication.org/index.php/bp/article/view/1042