Dimethyl Sulfoxide and Their Toxicity

  • Samiaa Jamil Abdulwahid Kurdi University Putra Malaysia
  • Nur-Fazila Saulol Hamid University Putra Malaysia
  • Yazan Ranneh University Putra Malaysia
  • Goh Yong Meng University Putra Malaysia
  • Zailina binti Hashim University Putra Malaysia
Keywords: DMSO, Clinacanthus nutans, mice, rat, toxicity

Abstract

The aim of the present mini-review was to report a toxic effect of dimethyl sulfoxide (DMSO) that has indicated to change the histology of the liver and kidney of rats. DMSO is a powerful co-solvent and often is used in early metabolic studies when compounds are poorly characterized and difficult to become soluble in water. To become soluble, they have to be dissolved in organic lipophilic solvents (vehicles). Following its conventional use, plant extract has been exposed to various intense and sub-acute toxicity studies to legitimize its toxicological security. Normally, DMSO has low fundamental toxicity yet plant extract when dissolved in 10% DSMO can cause noteworthy confined toxic impacts in the liver and kidney of rats. Be that as it may, vehicles currently in use have pleiotropic impacts, which are regularly obscure. Therefore, researchers ought to be cautious in the preparation and storage of substances before they are dispensed to animals. If this is not done, it may lead to accidental adverse effects on the animals and frequently result in inaccurate outcomes. In this mini-review, we summed up data on biological impacts of the DMSO most generally utilized lipophilic medication vehicles. Other than in experimental models, the information, where accessible, are presented on the impacts of solvents in therapeutic use in rodents. All in all, a few suggestions are given on the utilization of medication solvents in tests.

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Author Biographies

Samiaa Jamil Abdulwahid Kurdi, University Putra Malaysia

Department of Environmental and Occupational Health, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400 Serdang, Selangor Darul Ehsan, Malaysia.

Department of General Science, Faculty of Education, Soran Universitiy, Kurdistan Region of Iraq.

Nur-Fazila Saulol Hamid, University Putra Malaysia

Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, University Putra Malaysia, 43400 Serdang, Selangor Darul Ehsan, Malaysia.

Yazan Ranneh, University Putra Malaysia

Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400 Serdang, Selangor Darul Ehsan, Malaysia.

Goh Yong Meng, University Putra Malaysia

Department of Preclinical Sciences, Faculty of Veterinary Medicine, University Putra Malaysia, 43400 Serdang, Selangor Darul Ehsan, Malaysia.

Zailina binti Hashim, University Putra Malaysia

Department of Environmental and Occupational Health, Faculty of Medicine and Health
Sciences, University Putra Malaysia, 43400 Serdang, Selangor Darul Ehsan, Malaysia.

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Published
2019-07-28
How to Cite
Samiaa Jamil Abdulwahid Kurdi, Nur-Fazila Saulol Hamid, Yazan Ranneh, Goh Yong Meng, & Zailina binti Hashim. (2019). Dimethyl Sulfoxide and Their Toxicity. International Journal For Research In Biology & Pharmacy (ISSN: 2208-2093), 5(7), 09-18. Retrieved from https://gnpublication.org/index.php/bp/article/view/1031